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Studies

Trust the ingredients, which both the the European food safety authority (EFSA) and numerous studies have proven to have an effect on fertility, the reproductive system and sperm health. FertilUp contains the right ingredients in carefully measured quantities.
Transparent and without deception.

Studies on the effect of zinc and selenium on female and male fertility.

The role of zinc in male fertility and reproduction has also been confirmed by the European food safety authority. Groups with fertile men were reported to have higher zinc levels compared to infertile men. Numerous studies have shown that zinc levels and sperm quality are strongly correlated¹. Low zinc levels or deficiency can negatively affect male fertility by affecting testosterone levels and sperm quality ^2,3,4.

A meta-analysis of 17 studies investigating the relationship between zinc in seminal plasma and male fertility was conducted. The results showed that zinc supplementation had a significant effect on sperm volume, spermatozoa and sperm morphology ^1,4.

Many studies also highlight the importance of zinc in women ³⁶ for normal fertility and healthy pregnancy outcomes.

In a study involving more than 600 men, selenium in combination with vitamin E supplementation significantly improved several sperm parameters. 52.6% of participants improved sperm motility, morphology, or both, and 10.8% achieved spontaneous pregnancy⁵. Several other studies have shown similar results and support the use of selenium to improve fertility ^6,7 .

The use of selenium in women supports a healthy full-term pregnancy along with the development of the nervous and immune systems of the growing fetus ^8,37.

The European Food Safety Authority has also officially confirmed the role of zinc ^1,2 and selenium ^3,4 in male fertility and reproduction. Both are also key ingredients in the nutritional supplement FertilUp for men.

Fertility experts have proven that vitamin B12 plays an important role in sperm development. A study found that vitamin B12 supplementation can improve sperm vitality, motility and DNA integrity⁹.

Vitamin B is also very important for female fertility. The study showed that women with a higher concentration of B vitamins (including folic acid) in their blood also have fewer problems conceiving ^10,39.

When investigating CoQ10 levels, a study from 2019 involving 65 men showed that CoQ10 supplementation improves sperm count and motility ¹¹. Numerous other studies have also confirmed the impact of CoQ10 on sperm concentration and morphology ¹².

A study coducted in 2018 found that women who took 600 mg of CoQ10 for 3 months had a higher chance of conception (67% vs. 45%) and a live birth rate of 29% vs. 16% 13. Also, the study on women's reproductive health showed that coenzyme Q10 supplementation can improve the quantity and quality of egg cells in older women¹⁴.

Numerous studies³⁸ have proven that our way of life (how we eat and how we live) affects the health of the entire organism and also our fertility. Choose FertilUp - All the important ingredients in just 2 capsules per day.

Check out the effect of vitamin D3 on fertility.

Vitamin D is considered the sunshine vitamin, but as much as 40% of the world's population has too low levels of vitamin D. Deficiency can have a negative impact on women's fertility and pregnancy rate¹⁵. A study analyzing 188 women found that the pregnancy rate was 4x higher in women who had adequate levels of vitamin D compared to those who had lower levels^16,17.

In men, low vitamin D levels are associated with poorer sperm quality (reduced sperm count and motility) ^{18, 19, 20}. A study from 2018 found that couples in which men received vitamin D had nearly twice the pregnancy success rate; 35.6% vs. 18.3% ²⁰.

Evidence gathered in studies over the last decade advises the use of Omega-3 fatty acids, zinc and vitamins B, D3 and C for increased fertility and a healthy pregnancy.

Studies demonstrate the impact of Omega-3 fatty acids on overall health and fertility.

In women who regularly consumed Omega-3 fatty acids, higher levels were found to be associated with slower ovarian aging, better egg quality and improved fertility²¹. A 2018 study further supported this idea by showing that the probability of clinical pregnancy increased by 8% for every 1% increase in blood Omega-3 levels²².

A study examining the relationship between Omega-3 concentration in blood and key sperm parameters demonstrated that higher levels of Omega-3 are associated with higher sperm count and better motility and morphology²³. Many other studies have also proven that Omega-3 fatty acids affect male fertility and sperm ^24,25.

Vitamins E and C, folate and L-carnitine are also a very important part of FertilUp for a reason.

Vitamin E is a powerful antioxidant that many studies have linked to improved female fertility and healthy pregnancy³¹. In terms of male fertility, recent studies have shown that the consumption of vitamin E affects sperm motility and improves semen quality³⁰.

Folate is well known for supporting maternal health and fetal development during pregnancy. Studies have shown that folate can improve egg cell development and embryo quality²⁶.

Vitamin C is a powerful antioxidant and studies show that consuming vitamin C can increase blood antioxidant levels by up to 30% and it also works anti-inflammatory^28,29. A study where men took 2,000 mg of vitamin C per day for two months showed an increase in sperm count and motility, and after two months of vitamin C supplementation, sperm count more than doubled. In the same study, the % of motile sperm almost doubled from 31.2% motility to 60.1%. Notable improvements were also detected in shape/morphology²⁷.

In female fertility, the addition of antioxidants (vitamins C and E) to the diet has been shown to be very effective in combating oxidative stress, which can damage the egg cells, thus stimulating female reproductive functions.

L-carnitine is found in high concentrations in the male reproductive tract and plays an important role in sperm maturation and motility. Research has shown that L-carnitine may help support sperm motility and other aspects of male reproductive health^{32, 33, 34}.

What we eat and how we live affect the health of the entire organism, the reproductive system and fertility.

1. Jiang Zhao, Xingyou Dong, Xiaoyan Hu, Zhou Long,Liang Wang, Qian Liu, Bishao Sun, Qingqing Wang, Qingjian Wu and Longkun Lia:Zinc levels in seminal plasma and their correlation with male infertility: A systematic review and meta-analysis. Sci Rep. 2016; 6: 22386.

2. Urszula Marzec-Wróblewska, Piotr Kamiński, Paweł Lakota, Marek Szymański, Karolina Wasilow, Grzegorz Ludwikowski, Magdalena Kuligowska-Prusińska, Grażyna Odrowąż Sypniewska, Tomasz Stuczyński, Jacek Michałkiewicz: Zinc and iron concentration and SOD activity in human semen and seminal plasma, Biol Trace Elem Res. 2011 Oct;143(1):167-77.

3. Abasalt Hosseinzadeh Colagar, Eisa Tahmasbpour Marzony, Mohammad Javad Chaichi: Zinc levels in seminal plasma are associated with sperm quality in fertile and infertile men, Nutr Res. 2009 Feb;29(2):82-8.

4. Enrique F. Schisterman, PhD1; Lindsey A. Sjaarda, PhD1; Traci Clemons, PhD2; et al Douglas T. Carrell, PhD3; Neil J. Perkins, PhD1; Erica Johnstone, MD4; Denise Lamb, BSN4; Kayla Chaney, BA2; Bradley J. Van Voorhis, MD5; Ginny Ryan, MD5; Karen Summers, MPH5; Jim Hotaling, MD6; Jared Robins, MD7; James L. Mills, MD1; Pauline Mendola, PhD1; Zhen Chen, PhD8; Elizabeth A. DeVilbiss, PhD1; C. Matthew Peterson, MD4; Sunni L. Mumford, PhD1: Effect of Folic Acid and Zinc Supplementation in Men on Semen Quality and Live Birth Among Couples Undergoing Infertility Treatment. JAMA. 2020;323(1):35-48.

5. Joanna Pieczyńska Halina Grajeta : The role of selenium in human conception and pregnancy, J Trace Elem Med Biol; . 2015 Jan;29:31-8.

6. Mohammad K Moslemi, Samaneh Tavanbakhsh: Selenium–vitamin E supplementation in infertile men: effects on semen parameters and pregnancy rate; Int J Gen Med. 2011; 4: 99–104.

7. L Keskes-Ammar 1 , N Feki-Chakroun, T Rebai, Z Sahnoun, H Ghozzi, S Hammami, K Zghal, H Fki, J Damak, A Bahloul : Sperm oxidative stress and the effect of an oral vitamin E and selenium supplement on semen quality in infertile men, Arch Androl; . 2003 Mar Apr;49(2):83-94

8. Joanna Pieczyńska, Halina Grajeta: The role of selenium in human conception and pregnancy, J Trace Elem Med Biol. 2015 Jan; 29:31-8

9. C Abad 1 , M J Amengual, J Gosálvez, K Coward, N Hannaoui, J Benet, A García-Peiró, J Prats: Effects of oral antioxidant treatment upon the dynamics of human sperm DNA fragmentation and subpopulations of sperm with highly degraded DNA . 2013 Jun;45(3):211-6. doi: 10.1111/and.12003.

10. Audrey J Gaskins, Yu-Han Chiu, Paige L Williams, Jennifer B Ford, Thomas L Toth, Russ Hauser, Jorge E Chavarro: Association between serum folate and vitamin B-12 and outcomes of assisted reproductive technologies. Am J Clin Nutr. 2015 Oct; 102(4): 943–950.

11. Ahmed T Alahmar: The impact of two doses of coenzyme Q10 on semen parameters and antioxidant status in men with idiopathic oligoasthenoteratozoospermia. Clin Exp Reprod Med. 2019 Sep; 46(3): 112–118.

12. Giancarlo Balercia 1 , Fabrizio Mosca, Franco Mantero, Marco Boscaro, Antonio Mancini, Giuseppe Ricciardo-Lamonica, GianPaolo Littarru: Coenzyme Q(10) supplementation in infertile men with idiopathic asthenozoospermia: an open, uncontrolled pilot study. Fertil Steril. 2004 Jan;81(1):93-8.

13. Assaf Ben-Meir, Eliezer Burstein, Aluet Borrego-Alvarez, Jasmine Chong, Ellen Wong,Tetyana Yavorska, Taline Naranian, Maggie Chi, Ying Wang, Yaakov Bentov, Jennifer Alexis, James Meriano, Hoon-Ki Sung, David L Gasser, Kelle H Moley, Siegfried Hekimi, Robert F Casper and Andrea Jurisicova: Coenzyme Q10 restores oocyte mitochondrial function and fertility during reproductive aging, Aging Cell. 2015 Oct; 14(5): 887–895.

14. Yangying Xu,Victoria Nisenblat,Cuiling Lu,Rong Li, Jie Qiao,Xiumei Zhen, and Shuyu Wang: Pretreatment with coenzyme Q10 improves ovarian response and embryo quality in low-prognosis young women with decreased ovarian reserve: a randomized controlled trial. Reprod Biol Endocrinol. 2018; 16: 29.

15. Elisabeth Lerchbaum , Barbara Obermayer-Pietsch: Vitamin D and fertility: a systematic review, Eur J Endocrinol. 2012 May;166(5):765-78.

16. Giovanna Muscogiuri , Barbara Altieri , Cristina de Angelis, Stefano Palomba, Rosario Pivonello, Annamaria Colao , Francesco Orio:Shedding new light on female fertility: The role of vitamin D, Endocr Metab Disord.2017 Sep;18(3):273-28

17. B Rudick 1 , S Ingles, K Chung, F Stanczyk, R Paulson, K Bendikson: Characterizing the influence of vitamin D levels on IVF outcomes, Hum Reprod. 2012 Nov;27(11):3321-7.

18. Martin Blomberg Jensen 1 , Poul J Bjerrum, Torben E Jessen, John E Nielsen, Ulla N Joensen, Inge A Olesen, Jørgen H Petersen, Anders Juul, Steen Dissing, Niels Jørgensen: Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa, Hum Reprod. 2011 Jun;26(6):1307-17.

19. Christian Trummer , Stefan Pilz , Verena Schwetz, Barbara Obermayer-Pietsch, Elisabeth Lerchbaum: Vitamin D, PCOS and androgens in men: a systematic review, Endocr Connect.2018 Mar;7(3):R95R113

20. Martin Blomberg Jensen, Jacob Gerner Lawaetz, Jørgen Holm Petersen, Anders Juul, Niels Jørgensen: Effects of Vitamin D Supplementation on Semen Quality, Reproductive Hormones, and Live Birth Rate: A Randomized Clinical Trial, The Journal of Clinical Endocrinology & Metabolism, Volume 103, Issue 3, March 2018, Pages 870–881, https://doi.org/10.1210/jc.2017-01656

21. Deepika Nehra, Hau D Le, Erica M Fallon, Sarah J Carlson, Dori Woods, Yvonne A White, Amy H Pan, Lankai Guo, Scott J Rodig, Jonathan L Tilly, Bo R Rueda, Mark Puder: Prolonging the female reproductive lifespan and improving egg quality with dietary omega-3 fatty acids, Aging Cell. 2012 Dec;11(6):1046-54.

22. Y-H Chiu, A E Karmon, A J Gaskins , M Arvizu , P L Williams, I Souter, B R Rueda, R Hauser, J E Chavarro; EARTH Study Team: Serum omega-3 fatty acids and treatment outcomes among women undergoing assisted reproduction, Hum Reprod. 2018 Jan 1;33(1):156-165.

23. Mohammad Reza, Safarinejad Seyyed, Yousof Hosseini, FaridDadkhah, Majid AliAsgari: Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: A comparison between fertile and infertile men, Urology and Nephrology Research Center, Department of Urology, Shahid Modarress Hospital, Shahid Beheshti University (MC), Tehran, Iran

24. M. L. Falsig, C. S. Gleerup, U. B. Knudsen: The influence of omega-3 fatty acids on semen quality markers: a systematic PRISMA review. First published: 22 May 2019

25. Mohammad Reza Safarinejad and Shiva Safarinejad: The roles of omega-3 and omega-6 fatty acids in idiopathic male infertility, Asian J Androl. 2012 Jul; 14(4): 514–515.

26. Jolanda C Boxmeer 1 , Nick S Macklon, Jan Lindemans, Nicole G M Beckers, Marinus J C Eijkemans, Joop S E Laven, Eric A P Steegers, Régine P M Steegers-Theunissen: IVF outcomes are associated with biomarkers of the homocysteine pathway in monofollicular fluid, Hum Reprod. 2009 May;24(5):1059- 66.

27. Mohammed Akmal, J Q Qadri, Noori S Al-Waili, Shahiya Thangal, Afrozul Haq, Khelod Y Saloom: Improvement in human semen quality after oral supplementation of vitamin C, J Med Food. 2006 Fall;9(3):440-2

28. Sedigheh Ahmadi, M.Sc., Reihane Bashiri, M.Sc.,Akram Ghadiri-Anari, M.D. and Azadeh Nadjarzadeh, Ph.D.: Antioxidant supplements and semen parameters: An evidence based review; Int J Reprod Biomed. 2016 Dec; 14(12): 729–736

29. Ljiljana M. Popovic ,Nebojsa R. Mitic,Dijana Miric,Boban Bisevac,Mirjana Miric, Brankica Popovic: Influence of Vitamin C Supplementation on Oxidative Stress and Neutrophil Inflammatory Response in Acute and Regular Exercise, Volume 2015

30. E Kessopoulou 1 , H J Powers, K K Sharma, M J Pearson, J M Russell, I D Cooke, C L Barratt: A double- blind randomized placebo cross-over controlled trial using the antioxidant vitamin E to treat reactive oxygen species associated male infertility, Clinical Trial Fertil Steril. 1995 Oct;64(4):825-31.

31. Siti Syairah Mohd Mutalip, Sharaniza Ab-Rahim and Mohd Hamim Rajikin; Vitamin E as an Antioxidant in Female Reproductive Health, Antioxidants (Basel). 2018 Feb; 7(2): 22.

32. Elham Aliabadi, Ph.D., Malek Soleimani Mehranjani, Ph.D., Zahra Borzoei, M.Sc., Tahereh Talaei- Khozani, Ph.D., Hossein Mirkhani, Ph.D., and Hamed Tabesh, Ph.D.; Effects of L-carnitine and L-acetyl- carnitine on testicular sperm motility and chromatin quality. Iran J Reprod Med. 2012 Mar; 10(2): 77–82.

33. Dikmen Dokmeci: Oxidative stress, male infertility and the role of carnitines. Folia Med (Plovdiv). 2005;47(1):26-30.

34. Andrea Lenzi, Paolo Sgrò, Pietro Salacone, Donatella Paoli, Barbara Gilio, Francesco Lombardo, Maria Santulli, Ashok Agarwal, Loredana Gandini: A placebo-controlled double-blind randomized trial of the use of combined l-carnitine and l-acetyl-carnitine treatment in men with asthenozoospermia. Fertil Steril. 2004 Jun;81(6):1578-84.

35. Joanna Wojsiat , Jerzy Korczyński , Marta Borowiecka , Halina Małgorzata Żbikowska: The role of oxidative stress in female infertility and in vitro fertilization; Postepy Hig Med Dosw (Online). 2017 May 9;71(0):359-366.

36. Tyler Bruce Garner, James Malcolm Hester, Allison Carothers ,Francisco J Diaz :Role of zinc in female reproduction, Biol Reprod. 2021 May 7;104(5):976-994

37. Luiz Gustavo Lima , André Amaro Mamédio Dos Santos,Tiago Daniel Gueiber Ricardo, Zanetti Gomes, Camila Marinelli Martins , Andrielle Cristina Chaikoski: Relation between Selenium and Female Fertility: A Systematic Review, Rev Bras Ginecol Obstet. 2022 Jul;44(7):701-709.

38. Kinga Skoracka, Alicja Ewa Ratajczak, Anna Maria Rychter, Agnieszka Dobrowolska, Iwona Krela-Ka≈∫mierczak: Female Fertility and the Nutritional Approach: The Most Essential Aspects; Adv Nutr ; 2021 Dec 1;12(6):2372-2386

39. Jorge E. Chavarro, MD, ScD,a Janet W. Rich-Edwards, ScD, MPH,b,c,d Bernard A. Rosner, PhD,d,e and Walter C. Willett, MD, DrPHa,c,d : Use of multivitamins, intake of B vitamins and risk of ovulatory infertility; Author manuscript; available in PMC 2008 Sep 1.Published in final edited form as: Fertil Steril. 2008 Mar; 89(3): 668–676.

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